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ISSN : 1738-0294(Print)
ISSN : 2288-8853(Online)
Journal of Mushrooms Vol.11 No.1 pp.46-51
DOI :

꽃송이버섯 추출물의 항염활성 효과

최우석1, 신평균2, 유영복2, 노형준3, 김군도1*
1부경대학교 자연과학대학 미생물학과, 2농촌진흥청 국립원예특작과학원 버섯과, 3농촌진흥청 국립원예특작과학원 인삼특작부

Anti-inflammatory effects of Sparassis crispa extracts

Gun-Do Kim1*, Woo-Suk Choi1, Pyung-Gyun Shin2, Yoo Young Bok2, Noh Hyung Jun3
1Department of Microbiology, College of Natural Sciences, Pukyong National University, Busan 608-737, Republic of Korea
2Mushroom Research Division, National Institute of Horticultural & Herbal Science, Rural Development Administration, Eumseong 369-874, Republic of Korea
3Department of Herbal Crop Research, National Institute of Horticultural & Herbal Science, Rural Development Administration, Eumseong 369-873, Republic of Korea

Abstract

Sparassis crispa is a medicinal mushroom, which has been reported to have anti-cancer effect. In this study,we designed to investigate the effects of Sparassis crispa extracts on the production of nitric oxide (NO) in LPS-stimulatedRAW264.7 cells. The pre-treatment of the extracts prior to add LPS in RAW264.7 cells suppressed NO production and iNOSexpression at protein and mRNA levels. The phosphorylation of IĸBα was inhibited by the extracts, which was induced throughsuppressing the activation of NF-ĸB. Sparassis crispa extracts showed the effect on the down-regulation of STAT-1 activation ina dose-dependent manner. In LPS-stimulated RAW264.7 cells, NF-ĸB was translocated into the nucleus, while the treatmentof Sparassis crispa extracts induced to sequestered NF-ĸB in the cytosol. These experimental results determined that Sparassiscrispa extracts play a inhibitory role in inflammatory reactions via regulating NO production, which suggests potential as acomponent of inflammatory drugs.

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