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ISSN : 1738-0294(Print)
ISSN : 2288-8853(Online)
Journal of Mushrooms Vol.22 No.4 pp.192-198
DOI : http://dx.doi.org/10.14480/JM.2024.22.4.192

Anti-inflammatory effects of ganodermanontriol from Ganoderma lucidum in Raw 264.7 cells

Che-Hwon Park, Seong-Cheol Lee, Young-Jin Park*
Department of Medicinal Biosciences, College of Biomedical and Health Science, Konkuk University, Chungju 27478, Korea

Abstract

Ganoderma lucidum, a fungus of significant scientific interest that encompasses a diverse array of bioactive compounds, has been extensively investigated for its potential health-promoting and disease-preventing properties. Ganodermanontriol, a triterpenoid, is the principal active component contributing to its biological activities. This study aimed to explore the anti-inflammatory properties of ganodermanontriol and to evaluate its potential as a functional ingredient. The expression of inflammatory mediators, including tumor necrosis factor (TNF)-α and inducible nitric oxide synthase (iNOS), and nitric oxide (NO) production was significantly inhibited in ganodermanontriol (1.25–5 μg/mL)-treated compared to that of untreated lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages. Additionally, the phosphorylation of mitogen-activated protein kinases (MAPK), specifically p38 and c-Jun N-terminal kinase (JNK), was markedly inhibited in ganodermanontriol (3–5 μg/mL)-treated cells. These findings indicate that ganodermanontriol possesses significant potential as both a prophylactic and therapeutic agent for immune-related disorders, owing to its ability to modulate inflammatory responses.

영지 유래 가노더마논트리올의 RAW 264.7 세포주에 대한 항염 효과

초록

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